SURG-31. UTILITY OF TRANEXAMIC ACID (TXA) FOR RESECTION OF INTRACRANIAL MENINGIOMAS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract Due to its anti-fibrinolytic action, tranexamic acid (TXA) can be utilized help maintain hemostasis during surgical operations. With respect surgery for intracranial tumors, we hypothesize that TXA could mitigate blood loss resection of highly vascular tumors such as meningiomas. We therefore conducted a systematic review the literature and meta-analysis analyze effects administration in patients undergoing meningioma. Study inclusion criteria were (1) primary data articles describing use In this meta-analysis, which included four comparative studies, outcome measurements between non-TXA groups compared. Primary outcomes operative length, complications, transfusion requirements, estimated loss, postoperative Hb versus (control) groups. Pooled-comparative analysis was each these perioperative variables formal applied toward statistically significant parameters. A total 221 analyzed (110 TXA, 111 non-TXA). Patient age (p = 0.1632), gender 0.8317), tumor location -.8334) similar control associated with decreased complication rate (logRR: -0.85; CI95% -1.49 -0.22; p 0.0087), requirement -0.50; -0.92 -0.08; 0.0039), reduced (SMD: -1.76; -3.21 -0.31; < 0.0001), increased 0.46; -0.15 1.07; 0.0001). three trials, administered intravenously loading dose 20 mg/kg minutes preoperatively an intraoperative maintenance 1mg/kg/hr; one trial, design identical except infusion preoperative unspecified. may increasedpostoperative when perioperatively